Hamilton traveled to Reading on Monday night for a non-league game.
Reading topped Big Blue in straight sets: 25-13, 25-18, 25-9.
Samantha Fuller had 7 kills and 6 digs, while Madison Welch had 5 digs and Erika Scott secured 10 assists and 2 aces on the night.
Hamilton is now 3-17 on the season and 2-6 in the league. They will travel to Oak Hills on Thursday for their final GMC contest of the year.